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1 ). To prioritize associated SNPs for observe up analyses, we used a Bayesian method to derive the smallest set of variants that included the causal variant with ninety five% likelihood (ninety five% credible set) ( 7 ). Five SNPs were included in this 95% credible set ( SI Appendix, Desk S1 ). We then carried out a replication affiliation evaluation of these 5 SNPs in an unbiased cohort of 222,358 males (2,957 circumstances and 219,401 controls) from the UK Biobank ( SI Appendix, Desk S2 ). All 5 credible set SNPs were significantly over the counter viagra related to erectile dysfunction in the replication analysis (P 0.01 required for multiple testing; all SNPs were associated P 10−13) in the same course as the GERA cohort results ( SI Apendix, Table S3 ). As evolutionary conservation is a strong marker of functional genomic sequences, we centered our observe-up analyses on one of the 5 SNPs, rs17185536, which was the one SNP positioned in an evolutionarily conserved area ( eight ).
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